Author

Patrick Holland

University of Colorado BoulderORCID 0009-0002-6507-7095Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Maciej A. A. WalczakiD· 2 shared Morgane HerloryiD· 2 shared Wyatt C. PowelliD· 2 shared Darya Poliyenko· 1 shared James Greenwood· 1 shared Karl Pankratz· 1 shared Luke Biggerstaff· 1 shared McKinley Nahum· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Maciej A. A. WalczakORCID

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2 papers

Recent·Most cited

N-Linked Glycosylation as a Driver of Tau Pathology and Neuronal Transmission

Tamara Basta, Morgane Herlory, Patrick Holland, Radmila Stojkovic, Wyatt C. Powell, Maciej A. A. Walczak

This study investigates how N-linked glycosylation affects Tau propagation and neuronal uptake by analyzing glycan site and structure effects on Tau-polyanion binding and seeding.

bioRxiv · Dec 4, 2025 · PreprintNeuroscience

Post-Translational Modifications Control Phase Transitions of Tau

Wyatt C. Powell, McKinley Nahum, Karl Pankratz, Morgane Herlory, James Greenwood, Darya Poliyenko, Patrick Holland, Ruiheng Jing, Luke Biggerstaff, Michael H. B. Stowell, Maciej A. A. Walczak

This study investigates how AD-specific post-translational modifications affect Tau self-assembly into PHFs, finding that phosphorylation generally inhibits aggregation while acetylation has variable effects.

ACS Central Science · Nov 13, 2024Peer-reviewedBiophysics