Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2-autoreceptor activity
Matthew Domenic Lycas, Aske Lykke Ejdrup, Andreas Toft Sørensen, Nicolai O. Haahr, Søren H. Jørgensen, Daryl A. Guthrie, Jonatan Fullerton Støier, Christian D. Werner, Amy Hauck Newman, Markus Sauer, Freja Herborg, Ulrik Gether
The paper uses super-resolution microscopy to show that dopamine transporter (DAT) in neurons exists in dynamic nanodomain and unclustered configurations, regulated by excitatory drive and D2-autoreceptor activity.
Cell Reports · Sep 1, 2022Peer-reviewedNeuroscience