Freja Herborg

Membrane curvature association of amphipathic helix 8 drives constitutive GPCR endocytosis

The paper identifies amphipathic helix 8 as a driver of constitutive GPCR endocytosis through membrane curvature association.

Injectable 3D microcultures enable intracerebral transplantation of mature neurons directly reprogrammed from patient fibroblasts

This study develops a 3D microculture method to generate mature dopamine neurons from patient fibroblasts, which can be transplanted into a Parkinson's disease rat model to form functional neuron grafts.

Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

The paper develops a computational model of dopamine dynamics in the striatum, revealing regional differences in dopamine transporter activity and receptor response kinetics.

Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorder

The paper identifies two disruptive SERT variants in treatment-resistant affective disorder patients and shows they cause partial loss-of-function, with one variant responsive to pharmacochaperoning.

Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and psychiatric disease

A mouse model with patient-derived DAT mutations reveals dopaminergic dysfunction linked to parkinsonism and psychiatric symptoms through behavioral and neurochemical changes.

Behavioral encoding across timescales by region-specificdopamine dynamics

This study uses dopamine sensors and machine learning to analyze how dopamine dynamics in the dorsal and ventral striatum of mice correlate with behavioral patterns during exploratory behavior.

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2-autoreceptor activity

The paper uses super-resolution microscopy to show that dopamine transporter (DAT) in neurons exists in dynamic nanodomain and unclustered configurations, regulated by excitatory drive and D2-autoreceptor activity.

Multimodal Detection of Dopamine by Sniffer Cells Expressing Genetically Encoded Fluorescence Sensors

This paper introduces a method to detect dopamine using genetically encoded fluorescent sensors in vitro and ex vivo, demonstrating its application for measuring dopamine release, uptake, and efflux.

A dominant-negative variant in the dopamine transporter PDZ-binding motif is linked to parkinsonism and neuropsychiatric disease

The paper identifies a dominant-negative DAT variant linked to parkinsonism and neuropsychiatric disease through functional and in vivo studies.

Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals

This study shows dopaminergic neurons form a unique axonal arbor with mostly non-synaptic terminals, expressing exocytosis proteins and being active, and highlights the role of specific proteins in synapse formation.

Disrupted PDZ-domain binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis and reward motivation

This study shows that disrupting the PDZ-domain binding motif of the dopamine transporter alters its nanoscale distribution and dopamine homeostasis, leading to changes in reward-related behaviors.