Matthew Domenic Lycas

The paper shows that mitochondrial DNA nucleoid distribution is controlled by pearling and cristae structure, revealing a mechanism for nucleoid spacing and segregation.

This study maps morphine-induced brain activity in male and female mice over time, revealing sex-specific and time-dependent patterns of c-Fos expression.

This paper introduces qExM, a method to estimate endogenous protein abundance in expanded samples, achieving a 9.4% mean percent error in nuclear pore complex subunit stoichiometry.

The paper identifies amphipathic helix 8 as a driver of constitutive GPCR endocytosis through membrane curvature association.

The paper develops a computational model of dopamine dynamics in the striatum, revealing regional differences in dopamine transporter activity and receptor response kinetics.

This study uses cryo-correlative light and electron microscopy to investigate the ultrastructure and dynamics of dopaminergic presynaptic release sites and identifies protein complexes and modulatory effects of pharmacological treatments.

This study uses dopamine sensors and machine learning to analyze how dopamine dynamics in the dorsal and ventral striatum of mice correlate with behavioral patterns during exploratory behavior.

The paper compares microdialysis and fiber photometry for measuring dopamine in awake mice after amphetamine exposure, finding good correlation between the two methods.

The paper uses super-resolution microscopy to show that dopamine transporter (DAT) in neurons exists in dynamic nanodomain and unclustered configurations, regulated by excitatory drive and D2-autoreceptor activity.

The paper identifies a dominant-negative DAT variant linked to parkinsonism and neuropsychiatric disease through functional and in vivo studies.

This study shows dopaminergic neurons form a unique axonal arbor with mostly non-synaptic terminals, expressing exocytosis proteins and being active, and highlights the role of specific proteins in synapse formation.

This study shows that disrupting the PDZ-domain binding motif of the dopamine transporter alters its nanoscale distribution and dopamine homeostasis, leading to changes in reward-related behaviors.

This study shows Rab2 is essential for bidirectional axonal transport of DCVs and lysosomes in Drosophila, with Arl8 also playing a role in DCV transport.