The paper develops a computational model of dopamine dynamics in the striatum, revealing regional differences in dopamine transporter activity and receptor response kinetics.

bioRxiv · Jul 3, 2024Neuroscience

Behavioral encoding across timescales by region-specificdopamine dynamics

Søren H. Jørgensen, Aske Lykke Ejdrup, Matthew Domenic Lycas, Leonie P. Posselt, Kenneth Lindegaard Madsen, Lin Tian, Jakob Kisbye Dreyer, Freja Herborg, Andreas Toft Sørensen, Ulrik Gether

This study uses dopamine sensors and machine learning to analyze how dopamine dynamics in the dorsal and ventral striatum of mice correlate with behavioral patterns during exploratory behavior.

Proceedings of the National Academy of Sciences · Feb 7, 2023Peer-reviewedNeuroscience

Within-animal comparison of microdialysis and fiber photometry in amphetamine-exposed mice

Aske Lykke Ejdrup, Joel Wellbourne-Wood, Jakob Kisbye Dreyer, Nina Guldhammer, Matthew Domenic Lycas, Ulrik Gether, Benjamin J. Hall, Gunnar Sørensen

The paper compares microdialysis and fiber photometry for measuring dopamine in awake mice after amphetamine exposure, finding good correlation between the two methods.

bioRxiv · Oct 27, 2022 · PreprintNeuroscience

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2-autoreceptor activity

Matthew Domenic Lycas, Aske Lykke Ejdrup, Andreas Toft Sørensen, Nicolai O. Haahr, Søren H. Jørgensen, Daryl A. Guthrie, Jonatan Fullerton Støier, Christian D. Werner, Amy Hauck Newman, Markus Sauer, Freja Herborg, Ulrik Gether

The paper uses super-resolution microscopy to show that dopamine transporter (DAT) in neurons exists in dynamic nanodomain and unclustered configurations, regulated by excitatory drive and D2-autoreceptor activity.

Cell Reports · Sep 1, 2022Peer-reviewedNeuroscience