Geissoschizine scaffolding enzymes shape monoterpene indole alkaloid biosynthesis
David Brelu-Brelu, Enzo Lezin, Emma Parker Miller, Duchesse‐Lacours Zamar, Mickaël Durand, Sitakanta Pattanaik, Barunava Patra, Nicolas Gautron, Caroline M. C. Birer-Williams, Thomas Perrot, Arnaud Lanoue, Audrey Oudin, Pierre Le Pogam, Mehdi A. Beniddir, Nathalie Giglioli‐Guivarc’h, , Vincent Courdavault
The paper identifies MDR proteins as regulators of geissoschizine biosynthesis, enhancing activity and diversifying stereochemical outputs through ternary complex formation with GS and SGD.
bioRxiv · May 3, 2026 · PreprintPlant Biology