A phytocannabinoid-sensitive phosphorylation switch converts endocannabinoids into alternative lipid GPCR activators
Anna C. Love, Yasuyuki Kihara, Hirotaka Mizuno, Kazufumi Nagai, David Coronel, Douglas J. Sheffler, Valerie P. Tan, Bradley S. Moore, Jerold J. M. Chun
The paper shows that phosphorylation of anandamide by DGKQ converts it into AEAp, which acts as a ligand for LPARs and MRGPRX4, linking eCB metabolism to Cannabis pharmacology.
bioRxiv · Sep 22, 2026 · PreprintBiochemistry