The Structure of the Picornaviral 2C:RNA holoenzyme: Molecular Basis of RNA binding and specificity by a AAA+ protein
Richard A. Pfuetzner, Louie Nathaniel Pinpin, Maëva Duboeuf, K Ian White, Adriana G Tubb, Bharti Singal, David Fernandez-Martinez, William R. Arnold, Axel T. Brünger, Garvey Mckenzie, Trevor R. Sweeney, Yousuf A. Khan
The paper determines the structure of the picornaviral 2C:RNA holoenzyme complex, revealing RNA binding mechanisms and conservation across viral families.
bioRxiv · Jun 10, 2026 · PreprintBiophysics