Bharti Singal

The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins

This study shows the ER membrane protein complex (EMC) acts as a chaperone to facilitate the assembly of voltage-gated calcium channels during their biogenesis.

The Structure of the Picornaviral 2C:RNA holoenzyme: Molecular Basis of RNA binding and specificity by a AAA+ protein

The paper determines the structure of the picornaviral 2C:RNA holoenzyme complex, revealing RNA binding mechanisms and conservation across viral families.

Glio-SERS: Label-Free Molecular Profiling of Plasma Extracellular Vesicles in Brain Tumors Using SERS and Artificial Intelligence

This study develops Glio-SERS, a method combining SERS and AI to profile plasma extracellular vesicles in brain tumors, showing 88% accuracy in distinguishing glioblastoma and meningioma from healthy controls.

The Adhesion GPCR ADGRL2 engages Gα13 to Enable Epidermal Differentiation

The paper identifies ADGRL2's role in epidermal differentiation through Gα13 activation and structural interactions, using CRISPR, Perturb-seq, and cryo-EM.

SNARE disassembly requires Sec18/NSF side-loading

The paper shows that Sec18/NSF disassembles SNARE complexes through side-loading, overcoming topological constraints by threading the SNARE domain through the ATPase rings.

Substrate-directed control of N-glycosylation in the endoplasmic reticulum calibrates signal reception at the cell-surface

The paper identifies an ER pathway that regulates N-glycosylation by modulating OST-A activity, impacting cell-surface signaling and tissue development.

A synthetic cell-free pathway for biocatalytic upgrading of one-carbon substrates

This study presents a cell-free biocatalytic system for converting one-carbon substrates into acetyl-CoA using a synthetic pathway called ReForm.