Axel T. Brünger

This study designs and validates protease-resistant antiviral peptides that inhibit SARS-CoV-2 fusion, showing improved efficacy in vitro and in vivo.

The paper determines the structure of the picornaviral 2C:RNA holoenzyme complex, revealing RNA binding mechanisms and conservation across viral families.

The paper reveals how NSF and SNAP proteins remodel SNARE complexes to enable synaptic transmission by disassembling syntaxin clusters through ATP hydrolysis.

The paper shows that Sec18/NSF disassembles SNARE complexes through side-loading, overcoming topological constraints by threading the SNARE domain through the ATPase rings.

This study uses cryo-electron tomography to visualize the in-situ structure and topography of AMPA receptor scaffolding complexes at molecular resolution.

The paper isolates and characterizes AMPA receptor trafficking vesicles from mouse brains, identifying known and novel proteins involved in their composition and function in synaptic plasticity.