Yousuf A. Khan

The paper determines the structure of the picornaviral 2C:RNA holoenzyme complex, revealing RNA binding mechanisms and conservation across viral families.

The paper introduces yakRNA Design, a language model that generates functional synthetic RNAs without 3D structural data, achieving efficient frame-shifting capabilities in ribosomes.

The paper reveals how NSF and SNAP proteins remodel SNARE complexes to enable synaptic transmission by disassembling syntaxin clusters through ATP hydrolysis.

The paper shows that Sec18/NSF disassembles SNARE complexes through side-loading, overcoming topological constraints by threading the SNARE domain through the ATPase rings.

ESM3, a 98-billion-parameter multimodal protein language model tokenized across sequence, structure, and function, designs a bright green fluorescent protein at 58% sequence identity to known fluorescent proteins.

This study uses cryo-electron tomography to visualize the in-situ structure and topography of AMPA receptor scaffolding complexes at molecular resolution.

The paper identifies a programmed ribosomal frameshifting event in PLEKHM2 mRNA that generates a constitutively active protein domain essential for lysosome transport and cardiac function.

The paper challenges the evidence for -1 frameshifting in CCR5 mRNA, arguing that the frameshifting mechanism does not lead to premature termination codon formation or mRNA destabilization via NMD.