Author
Howard Hughes Medical InstituteORCID 0000-0002-1741-2330Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Kailu Yang, Chuchu Wang, Francesco Topi…·Axel T. Brünger
This study designs and validates protease-resistant antiviral peptides that inhibit SARS-CoV-2 fusion, showing improved efficacy in vitro and in vivo.
Richard A. Pfuetzner, Louie Nathaniel Pinpin, Maëva Duboeuf…·Yousuf A. Khan
The paper determines the structure of the picornaviral 2C:RNA holoenzyme complex, revealing RNA binding mechanisms and conservation across viral families.
K. Ian White, Yousuf A. Khan, Kangqiang Qiu…·Axel T. Brünger
The paper reveals how NSF and SNAP proteins remodel SNARE complexes to enable synaptic transmission by disassembling syntaxin clusters through ATP hydrolysis.
Yousuf A. Khan, K. Ian White, Richard A. Pfuetzner…·Axel T. Brünger
The paper shows that Sec18/NSF disassembles SNARE complexes through side-loading, overcoming topological constraints by threading the SNARE domain through the ATPase rings.