CRISPR-Based DNA Imaging in Living Cells Reveals Cell Cycle-Dependent Chromosome Dynamics
Hanhui Ma, Li-Chun Tu, Ardalan Naseri, Yu-Chieh Chung, David Grunwald, Shaojie Zhang, Thoru Pederson
The paper uses CRISPR-Sirius to track chromosomal loci dynamics in living cells and finds cell cycle-dependent changes in DNA contortion and movement.
bioRxiv · Sep 29, 2017 · PreprintCell Biology