Author

Thoru Pederson

University of Massachusetts Chan Medical SchoolORCID 0000-0002-3703-7806Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:ChIP-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ardalan NaseriiD· 3 shared Hanhui MaiD· 3 shared Shaojie ZhangiD· 3 shared Jing ZhengiD· 2 shared Wei XieiD· 2 shared Xiao XiaoiD· 2 shared Ying Feng· 2 shared David Grunwald· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMolecular Biology

Ardalan NaseriORCID

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4 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJul 15, 2026

OTTR-CLASH: improved biochemical and bioinformatic identification of Argonaute 2-mediated microRNA-target RNA interactions

Paul D. Kaufman, Haibo Liu, Kai Hu…·Thoru Pederson

The paper introduces OTTR-CLASH, a method that improves the detection of miRNA-target interactions by using a modified RT and enhanced bioinformatics pipeline.

DOI 10.64898/2026.07.14.738487

experimental assay

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Molecular BiologyGenome biologyPeer-reviewedDec 1, 2020

Simultaneous Epigenetic Perturbation and Genome Imaging Reveal Distinct Roles of H3K9me3 in Chromatin Architecture and Transcription

Ying Feng, Yao Wang, Xiangnan Wang…·Hanhui Ma

This study uses EpiGo-KRAB to introduce H3K9me3 at specific loci and shows it forms heterochromatin-like domains without widespread gene repression.

65 citations

humanChIP-seq

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Molecular BiologybioRxivPreprintFeb 18, 2020

CRISPR-based Live Imaging of Epigenetic Modification-Mediated Genome Reorganization

Ying Feng, Yao Wang, Yang Chen…·Hanhui Ma

The paper develops a CRISPR-based system to image epigenetic modification effects on genome organization in living cells and shows it induces genomic relocation and H3K9me3 decoration.

DOI 10.1101/2020.02.18.954610

humanexperimental assay

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Cell BiologybioRxivPreprintSep 29, 2017

CRISPR-Based DNA Imaging in Living Cells Reveals Cell Cycle-Dependent Chromosome Dynamics

Hanhui Ma, Li-Chun Tu, Ardalan Naseri…·Thoru Pederson

The paper uses CRISPR-Sirius to track chromosomal loci dynamics in living cells and finds cell cycle-dependent changes in DNA contortion and movement.

DOI 10.1101/195966

humanDNA methylation

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