CD11b suppresses TLR7-driven inflammatory signaling to protect against lupus nephritis
Xiaobo Li, Veronica Villanueva, Viviana Jiménez, Billy Nguyen, Nishant Ranjan Chauhan, Samia Q. Khan, Jessica M. Dorschner, Mark A. Jensen, Khulood A. Alzahrani, Wei HuiTing, David J. Cimbaluk, David Changli Wei, Meenakshi Jolly, Darlah M. López-Rodríguez, Santiago Balza Pineda, , Vineet Gupta
This study shows that CD11b activation reduces TLR7-driven inflammation and protects against lupus nephritis through mechanisms involving suPAR suppression and immune complex reduction.
bioRxiv · Jul 26, 2024 · PreprintImmunology