Hepatobiliary Progenitor-like Reprogramming in Liver Metastases
Ajit Kumar Sharma, Nobuyuki Takahashi, Yingying Cao, Abhinav Joshi, Sophie Z. Zhuang, Amira Z Kazi, Michael Nirula, Sarthak Sahoo, Yang Zhang, Rajeswary Kumar, Seemadri Subhadarshini, Kanak Parmar, Melissa R. Mikolaj, Roshan L Shreshta, Tiyam Assadpour, , Anish Thomas
This study identifies hepatobiliary progenitor-like reprogramming in liver metastases, driven by TGF-β and hypoxia, and shows its association with poor survival.
bioRxiv · Jul 1, 2026 · PreprintCancer Biology