Author

Christopher A. Febres‐Aldana

National Institutes of HealthORCID 0000-0002-4754-1344Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:microscopy & imaging analysis· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Anish ThomasiD· 2 shared Kanak ParmariD· 2 shared Michael NirulaiD· 2 shared Sarthak SahooiD· 2 shared Yingying CaoiD· 2 shared Abhinav JoshiiD· 1 shared Ajit Kumar SharmaiD· 1 shared Alexander J. PfeiliD· 1 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Anish ThomasORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatially Organized Tertiary Lymphoid Structures Emerge in Small Cell Lung Cancer and Associate with Improved Survival

Yingying Cao, Michael Nirula, Paul W. Mallory, Sarthak Sahoo, Kanak Parmar, Christopher A. Febres‐Aldana, Anish Thomas

The paper identifies spatially organized tertiary lymphoid structures in small cell lung cancer and links their presence to improved patient survival.

bioRxiv · Aug 11, 2026 · PreprintCancer Biology

Hepatobiliary Progenitor-like Reprogramming in Liver Metastases

Ajit Kumar Sharma, Nobuyuki Takahashi, Yingying Cao, Abhinav Joshi, Sophie Z. Zhuang, Amira Z Kazi, Michael Nirula, Sarthak Sahoo, Yang Zhang, Rajeswary Kumar, Seemadri Subhadarshini, Kanak Parmar, Melissa R. Mikolaj, Roshan L Shreshta, Tiyam Assadpour, , Anish Thomas

This study identifies hepatobiliary progenitor-like reprogramming in liver metastases, driven by TGF-β and hypoxia, and shows its association with poor survival.

bioRxiv · Jul 1, 2026 · PreprintCancer Biology

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence within pulmonary fungal granulomas.

Yufan Zheng, Makheni Jean Pierre, Eduard Ansaldo, Hannah E. Dobson, Olena Kamenyeva, Chinaemerem U. Onyishi, Sarah Douglas, Christopher A. Febres‐Aldana, Pınar Engin Zerk, Irini Sereti, Jovany Jordan Betancourt, Kirsten Nielsen, Erin McCaffrey, Eric V. Dang

This study identifies alternatively activated myeloid cells as drivers of extracellular fungal persistence in pulmonary granulomas through T helper 2 cell signaling.

The Journal of Experimental Medicine · Mar 14, 2026Peer-reviewedImmunology

RRAS and RRAS2 mutations are recurrent oncogenic drivers in lung cancer and are sensitive to the pan-RAS inhibitor RMC-6236

Alexander J. Pfeil, Tom Zhang, Ryan Cheng, Marissa S. Mattar, Juan Luis Gomez Marti, Leo Gili, Rachel Lai, Inna Khodos, Rohan P Master, Jenna-Marie Dix, Andrea M. Gazzo, Kathryn Cecilia Arbour, Elisa de Stanchina, Christopher A. Febres‐Aldana, Marc Ladanyi, , Romel Somwar

This study identifies RRASQ87L and RRAS2Q72L mutations as recurrent oncogenic drivers in lung cancer and shows sensitivity to the pan-RAS inhibitor RMC-6236.

Clinical Cancer Research · Jan 16, 2026Peer-reviewedCancer Biology