Author

Ajit Kumar Sharma

National Institutes of HealthORCID 0000-0002-4811-7342Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Anish ThomasiD· 5 shared Chiori TabeiD· 3 shared Michael NirulaiD· 3 shared Parth Anil DesaiiD· 3 shared Yang ZhangiD· 3 shared Yue HuangiD· 3 shared Abhinav JoshiiD· 2 shared Amira Z KaziiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersCancer Biology

Anish ThomasORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small-Cell Lung Cancer

Chiori Tabe, Rajesh Kumar, Yue Huang, Michael J. Kruhlak, Ajit Kumar Sharma, Roshan L. Shrestha, Anish Thomas

This study identifies SAC competency as the determinant of sensitivity to KIF18A inhibition in SCLC, offering a predictive biomarker for targeted therapies.

Cancer Research Communications · Aug 26, 2026Peer-reviewedCancer Biology

Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8⁺ T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastases

Amira Z Kazi, Yingying Cao, Chirayu Mohindroo, Abhinav Joshi, Yang Zhang, Yue Huang, Chiori Tabe, Brett Schroeder, Þorkell Andrésson, Ajit Kumar Sharma, Anish Thomas

bioRxiv · Jul 31, 2026 · PreprintCancer Biology

Hepatobiliary Progenitor-like Reprogramming in Liver Metastases

Ajit Kumar Sharma, Nobuyuki Takahashi, Yingying Cao, Abhinav Joshi, Sophie Z. Zhuang, Amira Z Kazi, Michael Nirula, Sarthak Sahoo, Yang Zhang, Rajeswary Kumar, Seemadri Subhadarshini, Kanak Parmar, Melissa R. Mikolaj, Roshan L Shreshta, Tiyam Assadpour, , Anish Thomas

This study identifies hepatobiliary progenitor-like reprogramming in liver metastases, driven by TGF-β and hypoxia, and shows its association with poor survival.

bioRxiv · Jul 1, 2026 · PreprintCancer Biology

Metastatic organotropism in small cell lung cancer

Manan Krishnamurthy, Anjali Dhall, Sarthak Sahoo, Christopher William Schultz, Michelle A. Baird, Parth Desai, Jacob Odell, Nobuyuki Takahashi, Michael Nirula, Sophie Zhuang, Yue Huang, Brett Schroeder, Yang Zhang, Maria Sebastian Thomas, Christophe E. Redon, , Anish Thomas

This study identifies key cellular programs and pathways driving metastatic organotropism in small cell lung cancer using preclinical models and multiomic profiling.

Journal of Thoracic Oncology · Aug 1, 2025Peer-reviewedCancer Biology

Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation

Christopher William Schultz, Sourav Taru Saha, Anjali Dhall, Yang Zhang, Parth Anil Desai, Lőrinc Sándor Pongor, David A. Scheiblin, Valentin Magidson, Yilun Sun, Christophe E. Redon, Suresh Kumar, Manan Krishnamurthy, Henrique Bregolin Dias, Vasilisa Aksenova, Elizabeth G Giordano, , Anish Thomas

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

bioRxiv · Apr 29, 2025 · PreprintCancer Biology