Decoding Peripheral Tolerance: TCR Rules for pTreg differentiation in the Gut
Xinxin Chi, Charlotte H. Wang, Yollanda Franco Parisotto, William A. Nyberg, Vanja Cabric, Adélaïde Gélineau, Yi Cao, David L Owen, Jonas Ambjörnsson, Diane J. Mathis, Justin Eyquem, Chrysothemis C. Brown, Christophe O. Benoist
The paper shows that TCRs from Tregs are more effective than Tconv TCRs in driving pTreg differentiation, with distinct phenotypes based on antigen type.
bioRxiv · Oct 20, 2025 · PreprintImmunology