Uncovering the Regional and Cell Specific Bioactivity of Injectable Extracellular Matrix Biomaterials in Myocardial Infarction through Spatial and Single Nucleus Transcriptomics
Joshua M. Mesfin, Van Kim Ninh, Miranda D. Diaz, Michael B. Nguyen, Alexander Chen, Raymond M. Wang, Elyse G. Wong, Maria L. Karkanitsa, Jervaughn D. Hunter, Justin D. Yu, Benjamin D. Bridgelal, John-Paul A. Pham, Nika Taghdiri, David R. Calcagno, Colin Luo, , Karen L. Christman
This study uses spatial and single nucleus transcriptomics to analyze the regional and cell-specific effects of ECM hydrogel treatments in myocardial infarction, revealing differences in immune modulation and cardiac development between subacute and chronic administration.
bioRxiv · Jun 25, 2025 · PreprintBioengineering