Alexander Chen

An infusible decellularized extracellular matrix material binds to vasculature in infarcted myocardium and induces pro-reparative gene expression following acute myocardial infarction through inherent avidity and bioactive signaling

This study investigates the effects of different molecular weight components of an intravascularly infusible decellularized extracellular matrix (iECM) on vascular binding and pro-reparative gene expression after myocardial infarction.

Beyond the mean: genetic control of gene expression fidelity and dispersion

This paper shows that gene expression dispersion, not just mean expression, is a genetically controlled regulatory feature reflecting fidelity across species and cell types.

Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction

This study uses snRNAseq to identify cell-specific pro-repair responses induced by an infusible ECM biomaterial after myocardial infarction.

An Infusible Extracellular Matrix Biomaterial Improves Survival in a Model of Severe Systemic Inflammation

This study shows that an infusible extracellular matrix biomaterial improves survival in a mouse model of severe systemic inflammation by reducing inflammation and organ failure.

Uncovering the Regional and Cell Specific Bioactivity of Injectable Extracellular Matrix Biomaterials in Myocardial Infarction through Spatial and Single Nucleus Transcriptomics

This study uses spatial and single nucleus transcriptomics to analyze the regional and cell-specific effects of ECM hydrogel treatments in myocardial infarction, revealing differences in immune modulation and cardiac development between subacute and chronic administration.