Author

Benjamin D. Bridgelal

University of California San DiegoORCID 0009-0007-8986-5201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:deep learning· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alexander CheniD· 3 shared Colin LuoiD· 3 shared Karen L. ChristmaniD· 3 shared Kevin R. KingiD· 3 shared Michael B. NguyeniD· 3 shared Van Kim NinhiD· 3 shared Connor UhreiD· 2 shared Elyse G. Wong· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

Alexander ChenORCID

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3 papers

Recent·Most cited

BioengineeringAdvanced SciencePeer-reviewedOct 29, 2026

An infusible decellularized extracellular matrix material binds to vasculature in infarcted myocardium and induces pro-reparative gene expression following acute myocardial infarction through inherent avidity and bioactive signaling

Michael B. Nguyen, Alexander Chen, Quincy P. Lyons…·Karen L. Christman

This study investigates the effects of different molecular weight components of an intravascularly infusible decellularized extracellular matrix (iECM) on vascular binding and pro-reparative gene expression after myocardial infarction.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

BioengineeringAdvanced Healthcare MaterialsPeer-reviewedDec 18, 2025

Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction

Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons…·Karen L. Christman

This study uses snRNAseq to identify cell-specific pro-repair responses induced by an infusible ECM biomaterial after myocardial infarction.

4 citations

mousesnRNA-seq

𝕏 PostBluesky

BioengineeringbioRxivPreprintJun 25, 2025

Uncovering the Regional and Cell Specific Bioactivity of Injectable Extracellular Matrix Biomaterials in Myocardial Infarction through Spatial and Single Nucleus Transcriptomics

Joshua M. Mesfin, Van Kim Ninh, Miranda D. Diaz…·Karen L. Christman

This study uses spatial and single nucleus transcriptomics to analyze the regional and cell-specific effects of ECM hydrogel treatments in myocardial infarction, revealing differences in immune modulation and cardiac development between subacute and chronic administration.

DOI 10.1101/2025.06.25.661525

humanspatial transcriptomics

𝕏 PostBluesky