An optogenetic switch for the Set2 methyltransferase provides evidence for rapid transcription-dependent and independent dynamics of H3K36 methylation
Andrew M. Lerner, Austin J. Hepperla, Gregory R. Keele, Hashem A. Meriesh, Hayretin Yumerefendi, David Restrepo, Seth Zimmerman, James E. Bear, Brian A. Kuhlman, Ian J. Davis, Brian D. Strahl
This study uses optogenetic control of Set2 in yeast to show rapid, transcription-dependent H3K36me3 deposition and transcription-independent, stochastic demethylation.
Genome Research · Nov 1, 2020Peer-reviewedMolecular Biology