James E. Bear

The paper investigates how actin-membrane interface stress regulates Arp2/3-branched actin density during lamellipodial protrusion in response to extracellular conditions.

The paper identifies ACK as a regulator of LACL turnover by promoting actin branching to resolve arrested clathrin lattices in Arpc2 KO cells.

The paper quantifies fibroblast migration by analyzing force generation, cell shape, and motion, identifying discrete migratory states that are influenced by cytoskeletal organization.

This study shows that SUN2 in the nucleus regulates endothelial cell-matrix interactions, affecting vascular homeostasis and barrier function through microtubule and matrix metalloprotease mechanisms.

This study shows that local activation of PLC-γ1 via optogenetic tools can direct cell motility, revealing its role in chemotaxis beyond mere signaling.

This study shows TRIM9 promotes melanoma proliferation and alters cell morphology by modifying actin organization and adhesion.

SureCLIP and DrCLIP are methods for mapping endogenous protein interactions in cells and zebrafish without genetic manipulation, showing high sensitivity and identifying novel interactors.

This study measures cellular traction forces during confined migration through tunable microscale geometries, revealing that softer constrictions cause greater nuclear deformation due to internal contractile forces.

This study identifies Coro1A and TRIM67 as collaborators in netrin-dependent neuronal morphogenesis, showing their interaction is required for netrin responses.

This study identifies the NHSL1-A complex as a regulator of cell migration and chemotaxis by interacting with the Arp2/3 complex and modulating lamellipodia dynamics.

This study uses optogenetic control of Set2 in yeast to show rapid, transcription-dependent H3K36me3 deposition and transcription-independent, stochastic demethylation.