Mining for disease-associated microbial metabolites in an age-dependent model of multiple sclerosis
Annie Pu, Naomi M. Fettig, Alexandros Polyzois, Gary Y. C. Chao, Ikbel Naouar, Leah S. Hohman, Marissa A Fontaine, Michelle Zuo, Kevin Champagne-Jorgensen, Julia K. Copeland, Donny Chan, Katherine M Davis, Ruoqi Yu, Sarah Popple, Natalia A Carranza García, , Lisa C. Osborne
The paper identifies a microbial metabolite, indole 3-propionic acid, that can reverse non-remitting EAE in aged mice, suggesting therapeutic potential for progressive MS.
bioRxiv · May 27, 2024 · PreprintImmunology