Frank C. Schroeder

This paper introduces TAMOHA, a biochemical probe that enables comprehensive profiling of electrophilic metabolites, revealing thousands of previously uncharacterized species in E. coli, C. elegans, and mouse.

The paper compares whole-brain neural activity between sexes of C. elegans in response to various chemical stimuli, finding widespread sexual dimorphism in sensory neurons.

AIMe uses neuro-symbolic AI to predict and annotate small-molecule spectra, expanding the searchable chemical space by three orders of magnitude.

The paper identifies methyl 3-methyl-2-butenoate (MMB) as a male-derived volatile sex pheromone in nematodes, showing it is attractive to females and hermaphrodites and mimics a predator's chemical cues.

This study identifies raffinose as a dietary fiber that promotes bifidobacterial persistence in the gut during weaning, with implications for host health and inflammation.

The paper identifies novel alkaloid biosynthetic pathways in kratom by analyzing protein-protein interactions of a key enzyme and characterizing the enzymatic activities of its interaction partners.

This study identifies cyclohexyl acetate as a volatile sex pheromone mimic in Caenorhabditis nematodes, showing it acts as a male-specific attractant through a distinct sensory pathway.

The paper identifies four O-acetyltransferase genes in C. elegans essential for synthesizing volatile sex pheromones and reveals their dual role in producing both volatile and non-volatile pheromone components.

This study identifies a mechanism in C. elegans where lipidated neurohormones couple neurotransmitter signaling with lipid metabolism to regulate behavior.

This study shows lactate extends C. elegans lifespan via redox-driven lipid remodeling and involves SIRT1 and RICTOR.

The paper introduces PROMIS, a co-fractionation mass spectrometry technique integrated with chromatographic methods to map protein-metabolite interactions in E. coli, identifying 994 interactions and revealing novel functional insights.

The paper identifies a serotonergic neural circuit in C. elegans that suppresses aversive responses to conflicting olfactory stimuli by inhibiting aversive signals.

This paper identifies a cytochrome P450 gene variant that contributes to benzimidazole resistance in nematodes, independent of beta-tubulin mutations.

The paper identifies a microbial metabolite, indole 3-propionic acid, that can reverse non-remitting EAE in aged mice, suggesting therapeutic potential for progressive MS.

This study identifies how insulin-like peptide signaling in C. elegans ASJ neurons integrates sensory cues for dauer exit decision-making.

This study identifies sex-specific metabolomic differences in C. elegans, revealing sex-dependent metabolites and their biological roles.

The paper analyzes eIF4A sequence variants across eukaryotes to assess rocaglate sensitivity, revealing broad anti-pathogen potential and resistance patterns.

This study shows that vitamin B12-producing gut bacteria modulate excitatory neurotransmission in C. elegans by altering the methionine/SAM cycle and choline oxidation pathway.

The paper identifies the KGB-1 JNK MAPK pathway as essential for dauer formation in C. elegans in response to environmental stress.

This study shows that enteric bacteria produce tyramine, which modulates host sensory behavior and food choice in C. elegans by mimicking host neurotransmitters.

The paper identifies a highly responsive Arthrobotrys oligospora strain for studying fungal-nematode interactions and shows G-protein signaling is essential for trap formation.

The paper shows that a neurotransmitter receptor in C. elegans is co-opted for inter-organismal communication via pheromone sensing.

This study identifies a genetic variant in C. elegans that affects arsenic toxicity through differences in branched-chain amino acid metabolism.

The paper uses metabolome-scale GWAS to identify genetic loci controlling maize specialized metabolites, revealing chemical diversity and gene-metabolite associations.

This study shows that Caenorhabditis elegans can reverse attraction to ascaroside pheromones through associative learning involving food deprivation.

This study identifies sulfolipids secreted by predators that trigger fear-like responses in C. elegans through specific sensory neurons and signaling pathways.

This study shows that genetic sex modulates a shared chemosensory circuit in C. elegans, altering behavioral responses to sex pheromones through a cell-autonomous switch in the ADF neuron.