Author

Lisa C. Osborne

University of British ColumbiaORCID 0000-0002-7170-3235Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Andrew J SharoniD· 2 shared Blair K HardmaniD· 2 shared Madilyn Portas· 2 shared Marc Steven HorwitziD· 2 shared Naomi M. FettigiD· 2 shared Sarah PoppleiD· 2 shared Alexandros PolyzoisiD· 1 shared Annie PuiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Andrew J SharonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Helminth infection induces neuroimmune remodeling and clinical remission in a mouse model of multiple sclerosis

Naomi M. Fettig, Sarah Popple, Madilyn Portas, Andrew J Sharon, Arman Sawhney, Thomas Worthington, Blair K Hardman, Morgan Coburn, Ukpong B. Eyo, Mark C. Siracusa, Marc Steven Horwitz, Lisa C. Osborne

This study shows that helminth infection reduces CNS inflammation and demyelination in a mouse model of multiple sclerosis by promoting Th2 cells.

The Journal of Immunology · Jul 28, 2026Peer-reviewedImmunology

STAT1 expression in myeloid cells restrains murine norovirus-induced hepatitis and fibrosis

Andrew J Sharon, Madilyn Portas, J WRIGHT, Harshad Ingle, Blair K Hardman, Erin J. Goldberg, Jung Hee Seo, N. B. Abraham, Marc Steven Horwitz, Megan T. Baldridge, Blayne Amir Sayed, Lisa C. Osborne

This study shows that STAT1 in myeloid cells prevents MNV-induced hepatitis and fibrosis by controlling viral spread and myeloid cell activation.

bioRxiv · Apr 29, 2026 · PreprintImmunology

Mining for disease-associated microbial metabolites in an age-dependent model of multiple sclerosis

Annie Pu, Naomi M. Fettig, Alexandros Polyzois, Gary Y. C. Chao, Ikbel Naouar, Leah S. Hohman, Marissa A Fontaine, Michelle Zuo, Kevin Champagne-Jorgensen, Julia K. Copeland, Donny Chan, Katherine M Davis, Ruoqi Yu, Sarah Popple, Natalia A Carranza García, , Lisa C. Osborne

The paper identifies a microbial metabolite, indole 3-propionic acid, that can reverse non-remitting EAE in aged mice, suggesting therapeutic potential for progressive MS.

bioRxiv · May 27, 2024 · PreprintImmunology