SOX11 stimulates γδ T-cell differentiation and synergizes with LMO2 and MYCN to drive γδ-like T-cell acute lymphoblastic leukemia
André Almeida, Igor Fijałkowski, Kasper Thorhauge Christensen, Herlinde De Waele, Petri Pölönen, Marlies Vanden Bempt, Els Van Ammel, Sara T’Sas, Béatrice Lintermans, Panagiotis Ntziachristos, Kaat Durinck, Frank Speleman, Tom Taghon, Jan Cools, Charles Grenfell Mullighan, , Steven Goossens
This study identifies SOX11 as a driver of γδ-like T-cell acute lymphoblastic leukemia, showing its cooperation with LMO2 and MYCN to promote leukemogenesis.
bioRxiv · Jul 29, 2026 · PreprintCancer Biology