Jan Cools

This paper shows that sertraline and carfilzomib work together to kill T-cell cancers by disrupting metabolism and changing the immune environment.

This study identifies SOX11 as a driver of γδ-like T-cell acute lymphoblastic leukemia, showing its cooperation with LMO2 and MYCN to promote leukemogenesis.

SPLONGGET enables comprehensive genotype-phenotype analysis by integrating long-read single-cell genome, transcriptome, and open chromatin profiling in thousands of cells.

This study shows that targeting EZH2 and HDACs together induces ferroptosis in hematological malignancies by upregulating cholesterol biosynthesis and causing metabolic stress.

The paper identifies PSEN1 mutations that confer resistance to MRK-560 in T-ALL, revealing three distinct resistance mechanisms.