Frank Speleman

This study identifies SOX11 as a driver of γδ-like T-cell acute lymphoblastic leukemia, showing its cooperation with LMO2 and MYCN to promote leukemogenesis.

The paper shows that many reported RNA-chromatin interactions are technical artifacts caused by DNA off-targeting, not true biological interactions.

This study identifies RUVBL1 and RUVBL2 as druggable regulators of MYCN in neuroblastoma, showing their inhibition reduces MYC signaling and induces cell cycle arrest and apoptosis.

This study identifies synergistic effects of second-generation RRM2 and CHK1 inhibitors in neuroblastoma and sarcomas, showing enhanced replication stress and apoptosis.

This study shows AURKA promotes neuroblastoma malignancy and is suppressed by the PP2A pathway, with AURKA cooperating with MYCN in tumor progression.

The paper identifies NESPR, an adrenergic-specific lncRNA, as a regulator of neuroblastoma cell identity that prevents cell death by attenuating stress.

HTSplotter automates data processing, analysis, and visualization for in vitro perturbation screens, supporting multiple experimental types and time-course data.

This study benchmarks single cell RNA-seq technologies to assess their ability to detect transcriptional changes in NGP neuroblastoma cells after nutlin-3 treatment, finding heterogeneity in response not captured by bulk RNA-seq.

The paper presents a comprehensive dataset of TLX1 positive ALL-SIL lymphoblasts and primary T-ALL leukemias using polyA[+] and total RNA sequencing, ATAC sequencing, and ChIP sequencing, validated for quality and biological relevance.

The paper introduces a novel single cell strand-specific total RNA sequencing method that overcomes limitations of existing techniques and detects more genes, including non-polyadenylated ones.