Succinate Dehydrogenase-Deficient Cancer Cells Have Increased Susceptibility to Ym155 Induced DNA Damage
Qianjin Guo, Sooyeon Lee, N. Armstrong, Brian Lim, Rebecca C. Schugar, David Tomz, Haixia Xu, Anzel Zhen, Leor Needleman, Electron Kebebew, Justin P. Annes
This paper shows SDHB-deficient cancer cells are more sensitive to Ym155-induced DNA damage due to impaired DNA repair and succinate accumulation.
Endocrine Related Cancer · Feb 19, 2026Peer-reviewedCancer Biology