Qianjin Guo

This study identifies ABCB1 silencing in SDHB-deficient cancers and shows that vincristine improves progression-free survival in SDHB-mutant PPGL patients.

This paper shows SDHB-deficient cancer cells are more sensitive to Ym155-induced DNA damage due to impaired DNA repair and succinate accumulation.

This study uses patient-derived organoids to model pheochromocytomas and paragangliomas, revealing hypoxia-driven plasticity and therapeutic vulnerabilities, including responses to abemaciclib.

This study identifies CALHM2 as an ATP-regulated mitochondrial channel, showing it affects ATP levels and mTOR pathway activity, with implications for aging and disease.