Sustained Lysosomal Delivery of Enhanced Cy3-Labeled Acid Nanoparticles Restores Lysosomal pH in Retinal Pigment Epithelial Cells and Astrocytes
Jiaqi Li, Tianchen Wang, Wennan Lu, Davit Jishkariani, Andrew Tsourkas, Simon Kaja, Rohini M Nair, Joshua L. Dunaief, Claire H. Mitchell
This study develops Cy3-PLGA nanoparticles that restore lysosomal pH and function in retinal pigment epithelial and astrocyte cells, showing sustained delivery and retention for at least 28 days.
bioRxiv · Jun 16, 2025 · PreprintCell Biology