Claire H. Mitchell

Sustained Lysosomal Delivery of Enhanced Cy3-Labeled Acid Nanoparticles Restores Lysosomal pH in Retinal Pigment Epithelial Cells and Astrocytes

This study develops Cy3-PLGA nanoparticles that restore lysosomal pH and function in retinal pigment epithelial and astrocyte cells, showing sustained delivery and retention for at least 28 days.

Fluorescent identification of axons, dendrites and soma of neuronal retinal ganglion cells with a genetic marker as a tool for facilitating the study of neurodegeneration

This paper introduces a fluorescent Slc17a6-tdTomato mouse model for visualizing retinal ganglion cells and assessing neurodegeneration in vitro and in vivo.

Piezo1 and Piezo2 channels in retinal ganglion cells and the impact of Piezo1 stimulation on light-dependent neural activity

This paper shows that Piezo1 and Piezo2 channels are expressed in retinal ganglion cells and that their activation increases light-dependent neural activity and excitability, potentially linking to glaucoma progression.

Retinal microglial cells increase expression and release of IL-1β when exposed to ATP

This study shows that retinal microglial cells increase IL-1β expression and release when exposed to ATP via the P2X7 receptor, with effects distinct from astrocytes.

Evoked and spontaneous pain assessment during tooth pulp injury

This study assesses evoked and spontaneous pain following tooth pulp injury in mice using behavioral and molecular techniques to uncover pain mechanisms.