A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse
J. Wesley Maddox, Gregory J. Ordemann, Juan AM de la Rosa Vázquez, Angie Huang, Christof Gault, Serena R. Wisner, Kate Randall, Daiki Futagi, Nihal A. Salem, Dayne Mayfield, Boris V. Zemelman, Steven H. DeVries, Mrinalini Hoon, Amy Lee
The paper shows that a non-conducting Cav1.4 Ca2+ channel is essential for cone synaptogenesis, and its absence is compensated by Cav3 channels, leading to normal cone-mediated vision in knock-in mice.
eLife · Nov 12, 2024Peer-reviewedNeuroscience