Resilience to Endoplasmic Reticulum Stress Mitigates Calcium-Dependent Membrane Hyperexcitability Underlying Late Disease Onset in SCA6
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Geneviève Konopka, Vikram G. Shakkottai
This study identifies ER stress and HSP90-dependent UPR as mechanisms underlying delayed onset of SCA6 motor dysfunction and Purkinje cell spiking abnormalities.
Annals of Neurology · Sep 24, 2025Peer-reviewedNeuroscience