Ashwinikumar Kulkarni

This study compares the neurophysiological and molecular recovery from isoflurane anesthesia with sleep and sleep deprivation in mice, finding distinct gene expression patterns and EEG features.

This study identifies gene regulatory programs and cell type-specific molecular mechanisms underlying inferior colliculus development and auditory function.

The paper links hippocampal oscillatory activity during memory encoding to distinct molecular programs in anterior and posterior hippocampus using single-nucleus RNA sequencing and spatial transcriptomics.

The paper identifies novel cellular innovations in songbird pallium associated with vocal imitation, including specialized glutamatergic and GABAergic neurons and increased astrocyte proportions.

This study identifies ER stress and HSP90-dependent UPR as mechanisms underlying delayed onset of SCA6 motor dysfunction and Purkinje cell spiking abnormalities.

The paper shows that stimulation increases firing rates in pyramidal cells and strengthens cell assemblies in the human temporal cortex, linked to gene networks involving excitatory neurons and non-neurons.

The paper shows sleep loss alters glutamatergic synaptic properties in the neocortex, which are reversed by sleep, and links these changes to sleep-related genes and MEF2c/HDAC4 regulation.

This study shows FOXP1 regulates glutamatergic input development in striatal neurons, with potential therapeutic implications for FOXP1 syndrome.

The paper shows that Foxp1 and Foxp2 compensate for each other in D1-SPNs, and their loss causes motor and social deficits, which can be reversed by re-expressing Foxp1.

This study shows FOXP1 is essential for human basal radial glial cell proliferation and differentiation, leading to increased excitatory neuron production during cortical development.

This study integrates single-cell RNA-sequencing data from mouse striatal development to analyze trajectory patterns and transcription factor networks, finding extended postnatal development and regulatory effects of FOXP1 on oligodendrocytes.

This study shows that human CLOCK has extra-circadian functions in the neocortex, enhancing cognitive flexibility and neural connectivity through altered gene expression in excitatory neurons.

This study shows FoxP2 in the basal ganglia is essential for fluent birdsong initiation, termination, and syllable sequencing, with disruptions affecting dopamine receptor balance and vocal-motor sequencing.

The paper shows that FOXP1 reduces intrinsic excitability in D2 striatal projection neurons by increasing potassium currents through transcriptional activation of KIR and KLeak channels.

This study identifies MEF2C as essential for the biological responses to sleep loss, including gene expression changes and synaptic strength recovery.

This study uses single-cell RNA-sequencing to investigate Foxp1's role in striatal development, identifying cell-type-specific transcriptional mechanisms and functional deficits linked to FOXP1 mutations.

This paper links brain oscillations to gene expression in human patients, identifying gene modules associated with memory encoding and neuropsychiatric disorders.

This study shows that cortical Foxp2 is essential for behavioral flexibility and dopamine D1 receptor expression, with effects on cell type composition and gene expression in the neonatal cortex.