An shRNA screen in primary human beta cells identifies the serotonin 1F receptor as a negative regulator of survival during transplant
Rebecca A. Lee, Deeksha Gambhir, Vinh Q Nguyen, Xi‐Ping Huang, Yaohuan Zhang, Kaavian Shariati, Nicholas Yiv, Rebecca C. Schugar, Justin P. Annes, Bryan L. Roth, Gregory Ku
The paper identifies the serotonin 1F receptor as a negative regulator of human beta cell survival during transplant and demonstrates a small molecule antagonist that improves glycemia in islet transplants.
bioRxiv · May 1, 2024 · PreprintCell Biology