Vinh Q Nguyen

This study shows Optineurin deficiency disrupts the endolysosomal network and impairs xenophagy, leading to increased Mycobacterium tuberculosis growth and necrotic cell death.

This study shows Tax1bp1 promotes Mtb growth in alveolar macrophages and enhances inflammatory responses, while restricting Mtb in bone marrow-derived macrophages.

The paper identifies the serotonin 1F receptor as a negative regulator of human beta cell survival during transplant and demonstrates a small molecule antagonist that improves glycemia in islet transplants.

The paper identifies five discrete metabolic domains in the mouse and human small intestine using transcriptional signatures and machine learning, showing how diet influences domain properties.