Cell BiologybioRxivPreprint
An shRNA screen in primary human beta cells identifies the serotonin 1F receptor as a negative regulator of survival during transplant
Rebecca A. Lee, Deeksha Gambhir, Vinh Q Nguyen…·Gregory Ku
The paper identifies the serotonin 1F receptor as a negative regulator of human beta cell survival during transplant and demonstrates a small molecule antagonist that improves glycemia in islet transplants.
DOI 10.1101/2024.05.01.591950