Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons
John D. Graef, Hao Wu, Carrie Ng, Chicheng Sun, Vivian Villegas, Deena Qadir, Kimberly Jesseman, Stephen T. Warren, Rudolf Jaenisch, Angela M. Cacace, Owen B. Wallace
The paper shows that restoring over 5% FMRP expression or 20% FMRP-positive neurons in FXS neurons normalizes hyperactivity.
European Journal of Neuroscience · Dec 26, 2019Peer-reviewedNeuroscience