John D. Graef

This study shows that elevated alpha-synuclein in neurons reduces microglial phagocytosis in a co-culture model derived from SNCA triplication iPSCs.

The paper shows that restoring over 5% FMRP expression or 20% FMRP-positive neurons in FXS neurons normalizes hyperactivity.

This study identifies pathology-inducing α-synuclein species in human brain tissue and shows that C-terminal antibodies can immunodeplete them.