Hao Wu

LEGEND integrates scRNA-seq and spatial transcriptomic data to identify co-expressed gene groups, revealing spatial coherence and context-specific gene functions.

This study identifies numerous selective sweeps and genes under artificial selection in indigenous and commercial chickens using re-sequencing and statistical analysis.

CeDAR improves cell-type-specific differential analysis in bulk omics data by incorporating cell type hierarchy, enhancing accuracy and power, especially for low abundance cell types.

This study transplants FXS patient-derived neurons into mice to study their development and finds FMR1-dependent changes in synaptic activity and morphology.

This study shows that elevated alpha-synuclein in neurons reduces microglial phagocytosis in a co-culture model derived from SNCA triplication iPSCs.

The paper shows that in fragile X syndrome, long-range heterochromatinization of distal synaptic genes with STR instability is reversible by overexpression of a pre-mutation-length CGG tract.

The paper shows that restoring over 5% FMRP expression or 20% FMRP-positive neurons in FXS neurons normalizes hyperactivity.

The paper develops a method to detect differential signals in high-throughput data from mixed cell-type samples and shows its superior performance through simulations and real datasets.