Co-delivered PD-L1 rescues the protective efficacy mediated by an AAV-expressed HIV-1 bNAb
Michael Kuipa, Abubakarr A. Koroma, I. Leguizamo, Priya Dhole, Yash Barot, Michelle Y.-H. Lee, Gregory K. Tharp, Shan Liang, Magdalen Chouinard, Stephanie Ehnert, Stacey Weissman, Casey Whitehead, Rachelle L. Stammen, Jennifer S. Wood, Elizabeth H. Curran, , Matthew R. Gardner
This study shows that co-delivering PD-L1 with an AAV-expressed HIV-1 bNAb reduces anti-drug antibodies and improves bNAb expression and protection against HIV in rhesus macaques.
bioRxiv · Jun 1, 2026 · PreprintImmunology