Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domains
Devina Thiono, Demetrios Samaras, Thanh T.N. Phan, Deanna Zhu, Ruby P. Shah, Izabella N. Castillo, Lawrence J. Forsberg, Lakshmanane Premkumar, Ralph Steven Baric, Shaomin Tian, Brian A. Kuhlman, Aravinda M. de Silva
This study evaluates a stabilized DENV2 E homodimer vaccine, finding it elicits broader neutralizing antibody responses targeting multiple E protein domains compared to the wild-type monomer.
Journal of Virology · Apr 16, 2025Peer-reviewedMicrobiology