A circadian clock in the blood-brain barrier regulates xenobiotic efflux from the brain
Shirley Zhang, Zhifeng Yue, Denice M. Arnold, Gregory Artiushin, Amita Sehgal
The paper shows that the Drosophila blood-brain barrier has a circadian permeability rhythm driven by a clock in perineurial glia, with nighttime increased permeability enhancing drug efficacy.
Cell · Mar 1, 2018Peer-reviewedNeuroscience