Zhifeng Yue

Glia mediate brain-wide activity and sleep behavior during sickness through an adrenergic-glutamatergic axis

This study identifies glia as key coordinators of sickness-induced sleep behavior through an adrenergic-glutamatergic axis in Drosophila.

Sleep controls peroxisomal abundance to reduce wake-induced brain oxidation

This study shows that sleep regulates peroxisomal abundance to reduce brain oxidation caused by wakefulness, with Pex16 playing a key role in sleep regulation and lipid metabolism.

Neutral lipid processing in glia is sexually dimorphic and promotes sleep through diacylglycerol catabolism

The paper identifies sex-specific lipid differences in Drosophila neurons and glia and links glial diacylglycerol catabolism to sleep promotion.

Modulation of RNA processing genes during sleep-dependent memory

The paper identifies RNA processing genes modulated during sleep-dependent memory in Drosophila and shows their effects on sleep and memory consolidation.

Sleepiness, not total sleep amount, increases seizure risk

The paper shows that sleepiness, not total sleep amount, increases seizure risk in Drosophila models by identifying the role of sleep-promoting circuits and serotonin receptors.

Ecdysone acts through cortex glia to regulate sleep in Drosophila

This study shows ecdysone acts through cortex glia to regulate sleep in Drosophila by modulating lipid metabolism.

A circadian clock in the blood-brain barrier regulates xenobiotic efflux from the brain

The paper shows that the Drosophila blood-brain barrier has a circadian permeability rhythm driven by a clock in perineurial glia, with nighttime increased permeability enhancing drug efficacy.