Acetylation-Primed SUMOylation Drives RORβ Turnover via a p300-SIRT1 Regulatory Axis
Timothy R. O’Leary, Denis Shutin, Nadeska I. Montalvan, Nereida M. Abad-Yang, Vuong Dang, Dean P. Edwards, Patrick R. Griffin, Mi Ra Chang
This paper identifies a post-translational regulatory axis involving p300 and SIRT1 that controls RORβ stability and transcriptional activity through acetylation and SUMOylation.
bioRxiv · Oct 30, 2024 · PreprintBiochemistry