Author

Timothy R. O’Leary

Scripps Research InstituteORCID 0000-0001-7865-7705Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Patrick R. GriffiniD· 3 shared Alexander D. HondrosiD· 1 shared Althea Hansel-HarrisiD· 1 shared Arkadi ShwartziD· 1 shared Dean P. Edwards· 1 shared Denis Shutin· 1 shared Douglas J. KojetiniD· 1 shared Guoyun KaoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

Patrick R. GriffinORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PAR-Driven Condensation Maintains Stalled Replication Fork Stability

Lei Zhang, Zeyu Zhang, Timothy R. O’Leary, Arkadi Shwartz, Guoyun Kao, Patrick R. Griffin, Yong Zhang

The paper identifies PAR-driven condensation as a mechanism that stabilizes stalled replication forks under proteasomal stress.

bioRxiv · Jan 8, 2026 · PreprintBiochemistry

Structural insights into IMP2 dimerization and RNA binding

Stephen A Zorc, Paola Munoz‐Tello, Timothy O’Leary, Xiaoyu Yu, Mithun Nag Karadi Giridhar, Alexander D. Hondros, Althea Hansel-Harris, Stefano Forli, Patrick R. Griffin, Douglas J. Kojetin, Raktim N. Roy, Michalina Janiszewska

This study determines the structural properties of full-length IMP2, revealing its dimeric conformation and RNA-induced changes, which may inform drug design.

Journal of Structural Biology · Sep 12, 2025Peer-reviewedMolecular Biology

Acetylation-Primed SUMOylation Drives RORβ Turnover via a p300-SIRT1 Regulatory Axis

Timothy R. O’Leary, Denis Shutin, Nadeska I. Montalvan, Nereida M. Abad-Yang, Vuong Dang, Dean P. Edwards, Patrick R. Griffin, Mi Ra Chang

This paper identifies a post-translational regulatory axis involving p300 and SIRT1 that controls RORβ stability and transcriptional activity through acetylation and SUMOylation.

bioRxiv · Oct 30, 2024 · PreprintBiochemistry