Patrick R. Griffin

PAR-Driven Condensation Maintains Stalled Replication Fork Stability

The paper identifies PAR-driven condensation as a mechanism that stabilizes stalled replication forks under proteasomal stress.

Structural insights into IMP2 dimerization and RNA binding

This study determines the structural properties of full-length IMP2, revealing its dimeric conformation and RNA-induced changes, which may inform drug design.

MT-125 Inhibits Non-Muscle Myosin IIA and IIB, Synergizes with Oncogenic Kinase Inhibitors, and Prolongs Survival in Glioblastoma

Structural proteomics defines a sequential priming mechanism for the progesterone receptor

This study uses structural mass spectrometry to reveal the sequential binding mechanism of progesterone receptor isoforms with co-regulatory proteins on target DNA.

Structural basis of context-dependent RORγt target gene activation on chromatin

This study identifies how RORγt mutations affect gene activation by altering chromatin binding modes, explaining context-dependent autoimmunity and host defense outcomes.

A ternary switch determines ERα LBD conformation

The paper identifies a ternary switch in ERα LBD that regulates receptor activity through distinct H12 conformations, revealing an apo state and its destabilization by mutations.

Acetylation-Primed SUMOylation Drives RORβ Turnover via a p300-SIRT1 Regulatory Axis

This paper identifies a post-translational regulatory axis involving p300 and SIRT1 that controls RORβ stability and transcriptional activity through acetylation and SUMOylation.

Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic Potential

This paper develops a selective non-muscle myosin II inhibitor, MT-228, with high brain penetration and efficacy in preclinical models, offering therapeutic potential for diseases like stimulant use disorder.

PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation

This paper shows that PPARG in osteocytes regulates bioenergetics and systemic energy metabolism in mice, independent of sclerostin levels, with sex-specific effects on mitochondrial function and insulin signaling.

Molecular glue CELMoD compounds are allosteric regulators of cereblon conformation

This study investigates how CELMoD compounds induce conformational changes in cereblon, enabling neosubstrate binding and informing drug design strategies.

Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease Activation

This study determines the cryo-EM structures of human LONP1 to elucidate the molecular mechanism of its proteolytic activation and regulation.

Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ

The paper resolves conflicting findings on heme's role in REV-ERBβ-NCoR binding by showing heme directly enhances their interaction through structural and biochemical analyses.